Artemisinin Derivatives, all are true except:

A They are second-line agents for the treatment of severe falciparum malaria.
B These drugs have highly selective toxicity against malaria is that parasitized erythrocytes concentrate artemisinin and its derivatives to concentrations 100-fold higher than those in uninfected erythrocytes.
C The artemisinin compounds are rapidly effective against the asexual blood forms of Plasmodium species but are not active against intrahepatic forms.
D The antimalarial effect of these agents results primarily from the active metabolite Dihydroartemisinin.

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