Which of the following statements explains the main difference between rheumatoid arthritis and osteoarthritis?

A Osteoarthritis is gender-specific, rheumatoid arthritis isn’t
B Osteoarthritis is a localized disease rheumatoid arthritis is systemic
C Osteoarthritis is a systemic disease, rheumatoid arthritis is localized
D Osteoarthritis has dislocations and subluxations, rheumatoid arthritis doesn’t